"Isolated in Cyber Space, Part 2", known as "Dreadful Regeneration Combo" in the Japanese version, is the one-hundredth episode of the Yu-Gi-Oh! second series anime. It first aired in Japan on March 26, 2002 and in the United States on November 8, 2003.
Yami Yugi continues his Duel with Gansley. Gansley appears to have a strong advantage.
Noah shows Kaiba and Mokuba a projection of their lives at the orphanage in an attempt to emotionally weaken them. After an angry outburst by Mokuba, Kaiba realizes that Noah is trying to turn them against each other.
They watch the day that Kaiba challenged Gozaburo to a chess match and won. Gozaburo had agreed to adopt the brothers if he lost. Present day Mokuba complains about Kaiba's change in attitude after that day and nearly falls into a bottomless pit after opening another virtual door.
Tristan and Duke escape the hallway by destroying the walls with axes. Outside they find Serenity being chased by a "Mad Sword Beast". The pair rescue her when Tristan leaps off of the castle's upper balcony onto the Beast's back and leads it into a stream.
Turn 6: Yugi
Due to the effect of "Yowie", Yugi skips his Draw Phase. "Obnoxious Celtic Guardian" attacks "Ipiria", but Gansley activates his Deck Master ability to negate the attack and inflict damage to Yugi equal to the ATK of "Obnoxious Celtic Guardian" (Yugi 1900 → 500) by Tributing "Ipiria" and "Yowie". Gansley then activates the effect of "Ruklamba", Tributing it to Special Summon two monsters from his hand whose combined ATK are 2000 or less. He Special Summons "Wall of Illusion" (1000/1850) and another "Ruklamba" (1000/2000) in Attack Position. Gansley's hand contains "Ashingray", "Melchid the Four-Face Beast", and a third copy of "Ruklamba".
Cut from the dub are images of other, happy children with their parents in the orphanage playground when Kaiba and Mokuba see their past, and an image of the empty playground was replaced by one of Mokuba sitting alone on a swing.
When Seto challenged Gozaburo to a game of chess with the stakes set at adoption, in the dub, Seto blackmailed Gozaburo, threatening to tell the news reporters that Gozaburo was scared of a challenge from a kid. In the original version, Gozaburo saw Seto had a strong look in his eyes and accepted the challenge out of respect.
The death of Kaiba and Mokuba's parents are retconned in the dub. Originally, they were stated to have died in the flashbacks shown in the Duelist Kingdom arc, while in this episode they simply 'disappeared.'
The following cards appeared in this episode. Cards in italics debuted here.