In the first movie Shougo Aoyama got a "Red-Eyes Black Dragon" card, but was too timid to use it. Yugi Muto uses it against Seto Kaiba for Shougo. He demonstrates how "Red-Eyes" brings potential by fusing it with "Meteor Dragon" to Summon "Meteor Black Dragon".
In the Yu-Gi-Oh! manga and anime "Red-Eyes Black Dragon" became one of the signature cards of Joey Wheeler after he won it from Rex Raptor in Duelist Kingdom. Joey used it and a few of its support cards throughout the series.
"Red-Eyes" based Decks typically focus on getting it into one of its many alternate forms, as on its own it is rather weak for a monster of its Level. Compared to its rival, the "Blue-Eyes White Dragon", it is very easy to upgrade and several Dragon-based Decks work well with this archetype of cards.
One of the oldest "Red-Eyes"-based Decks developed from the release of the Dragon's Roar Structure Deck is the Red-Eyes Darkness Dragon Deck, which focuses on powering up "Darkness Dragon" by sending Dragon-Type monsters to the Graveyard. "Cyberdark" monsters can be combined into this particular type of Deck to create the Cyberdarkness Deck. Another less commonly used Deck is a "Fusion Red-Eyes Deck", focusing on Fusion Summoning "B. Skull Dragon" and "Meteor B. Dragon" as quickly as possible, and possibly Special Summon their Material Monsters back from the Graveyard to swarm the field.
With the release of "Red-Eyes Darkness Metal Dragon" and "Red-Eyes Wyvern", the "Hopeless Dragon Deck" and its more aggressive "Disaster Dragon" counterpart have become popular, which utilize the effect of "Red-Eyes Darkness Metal Dragon" and its ability to revive Dragons from the Graveyard.