Yu-Gi-Oh! 5D's is set in the futuristic Domino City, divided into the upper-class "utopia" New Domino City and the isolated poverty-stricken Satellite island. Duel Monsters is now played on motorbike-like vehicles known as Duel Runners.
The protagonist, Yusei Fudo, finds himself battling the class system and the law in the hopes of retrieving "bonds" that were important to him and his friends. Yusei and the people he encounters end up reliving an Ancient Incan battle, involving the prophesied Signers, their antithesis the Dark Signers and the mysterious organization Iliaster.