Machine monsters are powerful, and in some cases, fearsome to face in battle. They rely on high ATK as well as a variety of powerful effects, and they have some of the strongest Fusion Monsters in the OCG/TCG, that can be made even more powerful with the ATK-doubling ability of "Power Bond", "Cybernetic Zone", or "Limiter Removal". Most Machine monsters have DARK, EARTH, or LIGHT Attributes. In the Yu-Gi-Oh! (second series anime) first season, they have the special ability of immunity against all type of magic and Spellcaster attacks. Their general strategy varies, but they often have the ability to negate the effects of specific opposing cards and/or destroy them. Machine monsters also have two of their own Structure Decks, i.e. Machine Re-Volt and Machina Mayhem.

Some of the numerous Machine archetypes include: "Ancient Gear", "Gadget", "Geargia", "B.E.S.", "Vehicroid", "Ally of Justice", "Machina", "Karakuri", Gimmick Puppet and "Meklord" (which has the "Meklord Emperor" and "Meklord Army" sub-archetypes).

Notable Machine series' include:"Cyber Dragon", "Cyberdark", "Cycler", "Gradius", "Machine King", "Gun Dragon", "Jinzo", and "VWXYZ".

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