Isis (神官アイシス Shinkan Aishisu) is a priestess that serves Pharaoh Atem in Ancient Egypt and wields the Millennium Necklace. Ishizu Ishtar is the reincarnation of Isis. She is named after the Egyptian goddess Isis.

A wise, kind and intelligent woman, she seems to share a close friendship with Mahad in the anime, as she converses with him before he goes off to fight Bakura for the Pharaoh's sake. She is able to sense his plight during the duel with Bakura, and utters his name with tears flowing down her cheeks. Isis alone senses Mahad's demise, and cries out his name tearfully, showing that she does care about him. Even three thousand years on, in the final duel with Atem and Yugi, when the Dark Magician makes his appearance, Ishizu notices "a deep pain in her heart". In the anime, she dies while facing Zorc in an attempt to buy Mana enough time to give Atem his Millennium Puzzle; however in the manga, she survives the battle with Zorc and goes on to become a Priestess under Pharaoh Seto, still wielding the Millennium Necklace.

Monster SpiritsEdit

• Spiria
• Winged Dragon, Guardian of the Fortress ^#1
• Mystical Elf