Immediately after the player claims the reward for Ishizu Ishtar's appropriate Character Unlock Mission, they will encounter Ishizu for the first time. She remains silent for a moment, before stating she didn't expect to ever stand on the "battlefield" again - something she did not expect from Kaiba. She then questions how she has her Millennium Necklace, having already given it to Yugi during Battle City, before she begins to wonder if this world has recreated the abilities she had during Battle City. Ishizu then wonders if this means Marik is in Duel World as well. She grows saddened, as she wonders if Kaiba has basically forced her to relive the horrors she faced back then.
Until the player manages to defeat Ishizu at least once, whenever they challenge Ishizu to a Duel, she says that she now understands that the player must defeat her if they are to proceed. She recognizes that this is her role in this world and prompts the player to defeat her in order to take control of their own destiny. However, she also warns the player that she will not make their Duel an easy one, claiming that the player will see that her strategies have no equal.
Until the player manages to defeat Ishizu at least once, whenever they lose to her, she announces that she won because her victory was never in doubt. She then offers the player a piece of advice: Although she has the power to see the future, that does not necessarily mean that there is only one, as the future can be changed. She reminds the player that they always have the power to change the future, and urges them to believe in their cards.
Upon Ishizu's first defeat, she will say, "Nicely done." She then tells the player that the path to the future is for them to choose, so they should choose wisely. However, she also tells them to not forget that she is forever a Duelist, as this means she may stand in their way again in the future. When that time comes, she says, the both of them should have an honorable Duel.
After the player redeems their final unclaimed reward for Ishizu Ishtar's Character Unlock Missions, they will encounter Ishizu again, who tells the player that she attained something in her previous Duel: the light of hope. She continues by saying that even if the future is overshadowed by despair, people have the ability to change the future. She admits she cannot foresee what awaits people in Duel World, but she will keep fighting for a brighter tomorrow, and that she'll battle using her cards (which includes the "Blast Held by a Tribute" card).
In the Draw Phase, instead of doing a normal draw, restores Life Points by 300. The skill can be used only three times per Duel.
In the Draw Phase, you can show the card you draw if it is a Fairy-Type monster. Then you restores your Life Points by 1000.
You can view the top card of both players' Decks until the end of the 5th turn.
Can be used each time your Life Points decrease by 1800. In the Draw Phase, instead of doing a normal draw, draw a random Gravekeeper's card.
No Mortal Can Resist
Can be used when your Life points are at least 1000 less than the opponent's. All monsters in the opponent's Graveyard changes to Skull Servant. This skill can only be used once per turn.
Until the end of the opponent's next turn, neither you nor the opponent can Special Summon monsters from the Graveyard. This skill can only be used once per Duel.
She currently is the only duelist to not have a 3d monster card summoning animation.
Whats more strange is that her main card is a trap card, "Blast Held by a Tribute", the other duelists use monsters as their main card, making her unique.
Another odd fact is she has dialogue for Agido, which she not only doesn't use in the anime but is not a Gravekeeper monster as well, however its most likely because Agido looks like a egyption object.
Card Specific Dialogue
When she declares a attack with that monster, she announces “Gravekeeper’s Curse”, "Gravekeeper's Curst, attack! Doomsday Purge!”
Whenever Ishizu Summons "Agido", she announces "I summon Agido!"
Most of the time when she declares a attack with that monster, she announces "I attack with Agido!"
When Agido is sent to the graveyard she announces "Agido's effect activates!"
Most of the time when she declares an attack with that monster, she announces "Gravekeeper's Spear Soldier, attack!" followed by "Lunging Spear Assault!"
Whenever Ishizu Summons "Gravekeeper's Visionary", a cut-in frame of Ishizu will briefly appear, and she'll announce "I shall play this card." She next announces the name "Gravekeeper's Visionary."
Most of the time when she declares an attack with that monster, she announces "Gravekeeper's Visionary, attack!"
Whenever Ishizu activates "Blast Held by a Tribute", after she says "I caught you!" she then announces "I activate my Trap Card! Blast Held by a Tribute!" which is followed by "The Tribute Summoned monster is destroyed the instant it attacks!"