This article is about a gameplay strategy. For the card of the same name, see Hand Destruction.

Hand Destruction is the strategy of winning by physically depriving your opponent of available strategies to devise, by making sure he doesn't have access to many cards, if at all.

Spirit Reaper, Don Zaloog, and Mefist the Infernal General are all capable of sending a card from your opponent's hand to the Graveyard. When Morphing Jar and Protector of the Sanctuary are used together, it is the ultimate in Hand Destruction by totally wiping out any hand your opponent had, and giving you, essentially, 5 free cards. Alternatively Disturbance Strategy can be used with the advantage, that your opponent can't fill his graveyard, but you don't get new cards. Forced Requisition and Card Destruction is another related strategy.

Other commonly used cards include:

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