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This is the list of every card that can destroy cards within a player's Main Deck with its effect.

All OCG/TCG "Destroys Main Deck" cards

 Japanese nameCard typeProperty
Chain Destruction連鎖破壊Trap Card
Normal Trap Card
Normal Trap Card
Chain Dispel連鎖解呪Trap Card
Normal Trap Card
Normal Trap Card
Crush Card Virus死のデッキ破壊ウイルスTrap Card
Normal Trap Card
Normal Trap Card
Lost WorldロストワールドSpell Card
Field Spell Card
Field Spell Card

All Anime "Destroys Main Deck" cards

 Japanese nameCard typeProperty
Chain Destruction (anime)連鎖破壊Trap Card
Crush Card Virus (later DM anime)死のデッキ破壊ウイルスTrap Card

All Manga "Destroys Main Deck" cards

 Japanese nameCard typeProperty
Chain Destruction (manga)連鎖破壊Trap Card

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