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  • The effect of "Ultra Evolution Pill" is a homage to the belief that dinosaurs evolved from reptiles. Dinosaurs and modern reptiles, however, are not closely related, and dinosaurs are more closely related to birds.
  • In the 4Kids dub of Yu-Gi-Oh!, the card is renamed "Ultra Evolution". The "Pill" is dropped from the cards name, and the pill on the card artwork has been digitally removed, due to FCC regulations regarding the display of drugs in anime.

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