In alchemy, it is said that the Philosopher's Stone is a legendary alchemical substance said to be capable of turning base metals (lead, for example) into gold (chrysopoeia) or silver. It was also sometimes believed to be an elixir of life, useful for rejuvenation and possibly for achieving immortality.
"Sabatiel" may roughly translate to "God's Sabbath".
In some video games which feature this card as a playable card, it is either Limited or Forbidden.
The design of the sphere in this card's artwork is akin to the one featured in the artwork of the card, "ZERO-MAX".
The OCG/TCG effect of this card may relate to the cards Jaden chose with its anime effect, as they all contained "Fusion" within its name and continues the idea Banner suggested when he gave Jaden this card (in the book) linking alchemy and fusion.