This can be used on your opponent's defense monster if "Twin-Sword Marauder" is used, or possibly another monster that can now attack twice, to inflict massive damage.
If a Attack Position weak monster is given control to your opponent, such as "Water Spirit", via "Creature Swap" or "Mystic Box". It can attack with one of your strong monsters, activate "Time Machine", and return that monster to your opponent's side of the field. Then, attack it with another of your monsters. This is especially effective if a battle searcher is used.
If a "Giant Kozaky" is taken out that was given to your opponent with an effect like "Give and Take", use this to revive "Giant Kozaky" again and 5000 damage will be dealt in a single turn, maybe more if battle damage is also dealt with the first attack.