Let your opponent destroy "Doctor Cranium" to use its effect to add one Level 5 or 6 monster to your hand. Then, use this card to revive it for Tribute Summon. If you control another monster, or have another monster to revive, you can use both of them for "Master Gig".
Assuming you have at least more than 3000 Life Points, and have lots of "Winda" and "Kamui" in your Graveyard along with Level 2 Psychic-Type Tuner (like "Esper Girl", for example), this can instantly enable Sphreez OTK option.
Since the damage happens right AFTER the monsters are Special Summoned, cards like "Chain Disappearance" and "Torrential Tribute" cannot be activated in response of the Special Summon. Encountering "Solemn Warning" also become less-risky, since you won't take damage anyway.
Since this card's effect damage can be somewhat hefty, there's high risk for playing this card in an aggressive Psychic decks. However, Decks that either have high defensive elements (like most "Gusto" Decks) or running Life-recovery cards like "Magical Android" or ""Psychic Lifetrancer" can mitigate this problem.
"Magical Android" is more preferable, since she's easy to Summon and unlike "Lifetrancer", which can only recover up to 1200 Life Points each turn (with banishing Psychics as cost), "Android" can recover up to 3000 Life Points without cost, the same as this card's damage when Summoning 5 Level 2 Psychic-Type monsters.
The monsters you can bring back for a combo are: "Doctor Cranium", "Mind Master", "Psychic Jumper". Use "Psychic Jumper" to switch monsters ("Doctor Cranium" and your opponent's monster). Tribute "Psychic Jumper" for the effect of "Mind Master", Summoning "Reinforced Human Psychic Borg". Then attack "Doctor Cranium" with "Mind Master". That leaves no weak monsters on your side of the field. Also, you can use "Inferno Reckless Summon" to Summon three "Reinforced Human Psychic Borgs".
Use "Mind Master" to Tribute one of your weaker Psychics to Summon out a Level 4, then you could Tribute that for a monster like "Storm Caller" to Synchro Summon "Hyper Psychic Blaster" using "Mind Master", "Doctor Cranium" and "Storm Caller".