During a Mirror Match. Use this card to keep your resources.
Against a "Magical Explosion" Deck, use this card while "Dark Magician" and a Dragon-type monster are on the field to Fusion Summon "Amulet Dragon", then use its effect to banish all of the Spells in your opponent's Graveyard. This is best used in response to your opponent activating said Trap, since you won't take any damage.
Similarly, it is also a good card to use in a Burn Deck. In the event that your opponent summons "Prime Material Dragon", activate this card to summon "Meteor Black Comet Dragon". To add insult to injury, you will be able to damage your opponent by sending another "Red-Eyes" Monster to the Graveyard.
Use "DNA Transplant" in order to Summon any of the "Elemental HERO" Fusion Monsters listed above.
With the release of Fusion Monsters that are a combination of Synchro Monsters and other Materials, this card can be used to take advantage of your opponent's monsters after they have been Synchro Summoned.
Your opponent's Warrior-type Monsters or Dragon-type Synchro Monsters can be used to fuse for "Dragon Knight Draco-Equiste".
Since "Fabled" monsters are capable of rapidly Summoning Synchro Monsters and have their effects activated when discarded, this card can be very powerful in a "Fabled" Deck. "Fabled" monsters have their effects activated in a separate chain, so they will resolve normally.
One tactic that yourself may like to use with this card is to activate this card as Chain Link 2 when foreseeing your opponent adding another card to the chain which would combo well with Chain Link 1.
The effect of "Super Polymerization" will then prevent them from using the second card for their combo.
Use this card right after your Fusion Materials have all attacked, attack with your newly Summoned Fusion Monster
You can then use "De-Fusion" to get back your Materials for a new set of attacks.
Activate "Ojama Trio" and use the opponent's "Ojama Tokens" to Special Summon "Ojama Knight". Alternately, Special Summon two copies of "Ojamagic" with "Magical Hats", and then use them to Special Summon "Ojama Knight".
At the end of your Battle Phase, "Multiple Piece" can be returned to your Extra Deck, allowing yourself to Special Summon "Big Piece" and "Medium Piece" and due to the effect of the latter, maybe even another "Small Piece". Going for a Synchro Summon