An alternative to the above strategy, is using "Grinder Golem" as a re-useable token generator. Special Summon "Grinder Golem" in defense. If you have any "Flip Flop Frog" on the field, activate its effect to flip face-down, then Flip Summon it to return "Grinder Golem" back to your hand. Repeat as needed. (Since summoning the two tokens is not optional, this will probably only be used once per turn unless you use "Mass Driver" or "Cannon Soldier".)
If you have 3 tokens left and "Slifer the Sky Dragon" in your hand, use them to Special Summon three copies of "Poison Draw Frog" to use. The trio serves as a double-edged sword, because they will not only be tribute fodder, but their effects will cause "Slifer" to have at least 3000 ATK and DEF when you summon him, due to their effects.
Such a move can be pulled off in a Frog/Dragon deck. Use "Dragon's Mirror" to banish five Dragon-type Monsters from your Graveyard and summon "Five-Headed Dragon" before giving it to your opponent with "Mystic Box"(Assuming you don't control a monster other than "Substitoad", "Crime" and "Punishment"). Attack it with "Crime" and "Punishment" for a whopping 9000 Battle Damage.
Use this effect to summon "Treeborn Frog"; then, activate the effect again, so you will have "Treeborn Frog" in your Graveyard to Special Summon it to summon more Frog monsters.
When using "Substitoad", as long as you have a "Dupe Frog" on the field, your opponents will not be able to destroy either of them by battle, thanks to "Dupe Frog's" effect. If you leave "Dupe Frog" in Defense Position (with a card like "Spirit Barrier" to prevent Piercing), then your opponents can't touch your Life Points through battle. Using this strategy, team it up with "Unifrogs" to constantly attack your opponent without worry of them being attacked themselves.
As an alternative to "Galaxy Serpent", you can use "Rescue Rabbit" to play "Flamvell Guard" and summon "Tyrant Red Dragon Archfiend". In the EXTREMELY rare case that you also have "The Claw of Hermos" and a Dragon in your hand, activate TRDA's effect to Nuke the field and activate it to summon "Red-Eyes Black Dragon Sword" and equip it to him, before attacking the opponent directly for a One Turn Kill.
Use this card with "One for One" to Special Summon "Substitoad". Normal summon another monster to the field and use "Substitoad's" effect to search out "Dupe Frog", then your opponent can't touch your Life Points.
If you have another monster on your side of the field, you can also summon this card and tribute said other monster and this card to summon two "Dupe Frog", to make your opponent unable to attack at all.
Special Summon this with "Kinka-byo" then activate "Substitoad's" effect by tributing itself. Because "Kinka-byo" returns to the hand during your End Phase, you can potentially do this once every turn.
If you have "Pot of Avarice" you can get an easy 2 card draw by repeatedly tributing the same monster until you have at least 5 monsters in the Graveyard, then use "Pot of Avarice" to return them to the deck and draw 2 cards.
If "Substitoad" is on the field and "Fishborg Blaster" is in your graveyard, you can discard cards from your hand to Special Summon "Fishborg Blaster", and immediately substitute him for a frog monster from your deck. This sends him back into the graveyard, allowing you to repeat the process. You can use this to facilitate the use of "Des Croaking", or perform a "Wetlands" OTK by swarming the field.
Use "Soul Exchange" to tribute your opponent's monster instead of your own then you get to run through the engine as soon as your first turn without having to tribute "Substitoad" for his own cost or do any extra special summoning.