- "Cockroach Knight" and "Black Ptera" can be exceptional when used alongside this card.
- This card works well with "Crystal Beast" monsters, as they can be treated as either monsters or Continuous Spells.
- They are also useful if you are using "Rainbow Dragon" as one of the Fusion Material Monsters.
- Use this monster's last effect with "Transmigration Break", to banish all cards from your opponent's Graveyard.
- The quickest way to get the Material Monsters for this card is using "Rainbow Path" for the "Rainbow Dragon" (or "Rainbow Dark Dragon") and "E - Emergency Call" or "Summoner's Art" for "Elemental HERO Neos". "Elemental HERO Prisma" can also stand in for "Neos".
- "Elemental HERO Neos Alius" might be a good alternative to "Neos", as it is more easily Summoned and is a decent beatstick.
- If you plan on using this card, you may as well also include in your Extra Deck some copies of "Elemental HERO The Shining", "Elemental HERO Absolute Zero" and "Elemental HERO Gaia". "Gaia" can be Summoned with any EARTH-monster and an "Elemental HERO" (and several "Crystal Beast" monsters are EARTH-Attribute); "Absolute Zero" can be Summoned by fusing "Crystal Beast Emerald Tortoise" with any "Elemental HERO"; "Elemental HERO Great Tornado" can be Summoned with "Cobalt Eagle" and "Sapphire Pegasus" and "The Shining" can be used with "Crystal Beast Ruby Carbuncle". This isn't limited to fusing them with "Neos", either - the above-mentioned cards, "Elemental HERO Prisma", "Elemental HERO Stratos" and "Elemental HERO Neos Alius" can also all be fused, so this will increase the flexibility of your Deck and prevent dead draws.
- This card's effect to return all cards in the opponent's Graveyard to the Deck works exceptionally well against "Destiny HERO", Dark counterpart, Zombie and other Decks that rely on Graveyard effects.
- "Future Fusion" is an excellent way to Summon "Rainbow Neos" very early in the game, without going through all the trouble of having to search out its components.
- If you're going to use "Future Fusion", include a copy of "Book of Moon". It will flip "Rainbow Neos" face-down and thus remove its bond to "Future Fusion" (neither card will be destroyed). Then, it simultaneously removes a weak point and provides "Rainbow Neos" with extra fodder for Spell/Trap removal. (This strategy will work with any "Future Fusion" Summon, for that matter.)
- Use this card with "Assault Armor" since you can Tribute one monster on your side of the field to make all of your opponent monster back to their Deck. Then, send "Assault Armor" from the field to the Graveyard. So you can perform an OTK if your opponent doesn't have any Spell/Trap Cards that destroy monsters. such as "Mirror Force".
- Use this card and "UFOroid" to Summon "UFOroid Fighter" with "Power Bond" and "Pikeru's Circle of Enchantment" to get its ATK to 11400.
- Using this card with "Honest" will make for a guaranteed 4500 damage when you attack or are attacked.
- This card does extremely well in Twilight Decks.
- "Deep Diver" can search any component for "Rainbow Neos" and it also can be used to Fusion Summon "Elemental HERO Absolute Zero".
- "Elemental HERO Neos"
- "King of the Swamp" (for "Polymerization")
- "Rainbow Dragon"
- Use "Fusion Gate" instead of "Polymerization" to Fusion Summon this card, and use "Fusion Gate" to active the second effect of "Rainbow Neos". Your opponent cannot use "Solemn Warning" to stop "Fusion Gate", and you don't have to waste a S/T Zones for "Fusion Gate".
- Though it cannot be used as a Fusion Material Monster, "Malefic Rainbow Dragon" can be run in this Deck as it likely runs "Fusion Gate" (a Field Spell Card). banishing "Rainbow Dragon" allows the player to use "Light of Redemption" and "Malefic Rainbow Dragon" can be used for the effect of "Rainbow Neos", for "Advance Draw" or "Allure of Darkness".
- Use "Stardust Dragon" or "Field Barrier" to protect your "Fusion Gate" from "Mystical Space Typhoon", then Tribute them for the first/second effects of "Rainbow Neos".
- You can also use "Malefic Stardust Dragon", "Malefic Rainbow Dragon", "Rainbow Dark Dragon" for "Elemental HERO Escuridao". Or use fuse all of them for "Five-Headed Dragon".