"Prickle Fairy" works well with "Brain Crusher". Any monster powerful enough to destroy "Brain Crusher" will have to attack "Prickle Fairy" first and the effect of "Prickle Fairy" will force it into face-upDefense Position, making it easy prey for "Brain Crusher".
Use the Gemini Effect of "Gigaplant" to Special Summon "Prickle Fairy" from your Hand or Graveyard.
Use "DNA Surgery" to make all face-up monsters into Insect-types (including "Prickle Fairy"). That way your opponent cannot attack as long as those two are on the field. Use cards like "Limit Reverse" to surprise your opponent and stop their attack while "Surgery" is on the field.
Use "Prickle Fairy" with "Gravity Axe - Grarl" to start locking opposing monsters in Defense Position.
"Prickle Fairy" can be equipped with "Heart of Clear Water", making her very difficult to eradicate.