- Use this card's effect with "Safe Zone" to prevent this card from being targeted by card effects or being destroyed.
- Alternatively, you could target a monster your opponent controls with "Safe Zone". If this card would be destroyed, simply send the "Safe Zone" to the Graveyard instead to simultaneously destroy your opponent's monster.
- This card works well in an "Inzektor" Deck, as all the members of that archetype are DARK monsters. "Inzektor Ladybug" in combination with "Inzektor Dragonfly" can help Summon this card.
- This card can also be used with "Rank-Up-Magic Astral Force" to Xyz Summon "Inzektor Exa-Beetle".
- This card can easily be Summoned with an "Evilswarm" Deck, as most of that archetype's members are Level 4 DARK monsters. "Evilswarm Mandragora" and/or "Evilswarm Castor" are good choices for Summoning this card, and "Evilswarm Ophion" makes a good target for this card's effect.
- Summon this card pretty easily by Normal Summoning any Level 4 DARK monster, then Special Summoning "Kagetokage" via its effect.
- If you have two of this card on your side of the field, use their effects on each other so both cannot be destroyed by card effects.
- Using this card's effect on "Vanity's Emptiness" will prevent its self-destruction effect.
- Use with "Imperial Custom" in a Trap monster Deck. "Custom" makes Trap monsters immune to destruction and this card protects "Custom"
- Using the "Tiki" Trap monsters would allow to destroy your opponent's monsters, and protect your own Trap monsters while doing so, making "Spirit Barrier" a nice choice, too.
- Use this card's effect on monsters that would otherwise be the focus of your opponent's destruction effects and therefore not worth Summoning, like "Perfect Machine King", "Emes the Infinity", or other high-Level monsters.
- Use this card's effect to target cards which give lasting advantage, like "The Creator", "Black Whirlwind", and others like them, or monsters that can't be destroyed by battle, like "Daigusto Sphreez".
- This card works well in a "Gravekeeper's" Deck, as many of its members are Level 4 DARK monsters, while its effect can be used to prevent the destruction of "Necrovalley".
- If you use this card's effect on "Number Wall", both cards can very well be immune to any type of destruction.
- This card can be summoned in a "Harpie" Deck through "Summoner Monk" and "Blackwing - Zephyros the Elite" to help protect "Harpies' Hunting Ground" from it's own effect.
- You can use this card's effect on "Stardust Spark Dragon", and use the effect of "Stardust Spark Dragon" on this card, then you will have 2 nearly indestructible monsters as long as they are face-up. Equip both with "Mist Body" to have a improvement on this combo.
- You can circumvent the self-destruction effect of "Heart of Clear Water" by first setting it, then activating the effect of "Number 66", targeting the set card. After that, you can then activate the Spell, equipping it to any monster of your choice.