Level 4 monsters like "Dancing Fairy" allow yourself to gain LP frequently. When they are no longer to be used, they can Summon Rank 4 monsters like "Number 80: Rhapsody in Berserk" that "Manipulator of Souls" that easily can be equipped with.
"Rhapsody in Berserk" is usually the best choice for a Rank 4 Summon in a "Manipulator" Deck, since it can be easily upgraded to its "Number C" form using the second effect of "Don Thousand's Throne". (The first effect is great for "Manipulator" itself.) "Rhapsody" and/or its "Number C" form also boost the ATK of "Manipulator".
"Tri-and-Guess" can (at the cost of revealing both players' Extra Decks) boost your Life Points and this card's ATK by 3000 as well as inflicting the same amount as damage to your opponent's Life Points if used successfully.
"Aegis of Gaia" can do the same, at the risk of potentially losing the 3000 gained LP later.
If there is a bent on abusing this card's LP effect, there will often be a tons of LP (much more than may needed). Cards that allow yourself to pay lots of LP can be used at their fullest potential, provided this card's effect is already abused, or there is a confident that it can survive long enough to do so.
Like its "Chaos" counterpart, "Manipulator" is extremely vulnerable on its own, and will usually require some backup to survive long enough for its effects to reach full potency. If one combines "Pixie Ring" with powerful support monsters your opponent will be unable to attack "Manipulator", which makes for useful protection given that this card has 0 ATK and DEF to start. Later, once "Manipulator" gains some ATK it can provide the same protection to other monsters.