If the opponent is Top-Decking, "Neo-Spacian Grand Mole" can create a "Mole Lock". If the opponent Sets a monster, use "Grand Mole" to bounce the Set monster (it won't be flipped face-up) and re-Summon "Grand Mole". If the opponent Summons and attacks "Grand Mole", use its effect, then Summon it the next turn and attack directly.
Combine this card with "Jinzo" to make sure that "Neo-Spacian Grand Mole" is not impeded by Traps like "Skill Drain". This way, "Jinzo" will be able to attack while "Grand Mole" gets rid of monsters the opponent Sets.