- This card can upgrade "Neos"-themed Decks considerably, as many of them focus on Contact Fusions.
- Be cautious of its use, however, as any monster Summoned by this card cannot be Special Summoned again through normal means, such as "Call of the Haunted". This drawback, however, can be circumvented by using "Contact Out" and then redoing that same Contact Fusion.
- If you focus on the "Neos" Fusion Monsters that utilize 2 "Neo-Spacians" to be Special Summoned, a combo of this card and "Contact Out" can also help Summon any other monsters that require 3 Tributes, i.e. "Egyptian Gods", "Wicked Gods", "Destiny HERO - Plasma", "Gilford the Lightning", "Moisture Creature", "Beast King Barbaros".
- Use "Future Fusion" and target "Elemental HERO Divine Neos" to help you access the "Neos" Fusions more quickly.
- You can also Summon "Elemental HERO Neos Knight" with this card, but since the effect of this card does not Fusion Summon, "Neos Knight" will not gain ATK from its own effect.
- If you use "Convert Contact" in tandem with this card, not only can you dump 2 "Neo-Spacian" monsters into the Graveyard, but you can also draw cards.
- Use with "Elemental HERO Prisma" to become "Elemental HERO Neos". If you already control another "Neos" (such as with "O - Oversoul") and get a Level 7 Contact Fusion monster, you can Xyz Summon a Rank 7 monster rather than lose it at the end of the turn if you don't have "Contact Out" or "Neo Space".
- "Painful Choice" can help you deposit "Elemental HERO Neos" and the necessary "Neo-Spacian" monsters for your Fusions into your Graveyard.
- "Elemental HERO" Fusion Monsters that list "Elemental HERO Neos" as Material:
|Japanese name||Secondary type||Attribute||Type||Level/ Rank||ATK||DEF|
|Elemental HERO Air Neos||Ｅ・ＨＥＲＯ エアー・ネオス||WIND||Warrior||7||2500||2000|
|Elemental HERO Aqua Neos||Ｅ・ＨＥＲＯ アクア・ネオス||WATER||Warrior||7||2500||2000|
|Elemental HERO Chaos Neos||Ｅ・ＨＥＲＯ カオス・ネオス||DARK||Warrior||9||3000||2500|
|Elemental HERO Dark Neos||Ｅ・ＨＥＲＯ ブラック・ネオス||DARK||Warrior||7||2500||2000|
|Elemental HERO Flare Neos||Ｅ・ＨＥＲＯ フレア・ネオス||FIRE||Warrior||7||2500||2000|
|Elemental HERO Glow Neos||Ｅ・ＨＥＲＯ グロー・ネオス||LIGHT||Warrior||7||2500||2000|
|Elemental HERO Grand Neos||Ｅ・ＨＥＲＯ グラン・ネオス||EARTH||Warrior||7||2500||2000|
|Elemental HERO Magma Neos||Ｅ・ＨＥＲＯ マグマ・ネオス||FIRE||Warrior||9||3000||2500|
|Elemental HERO Marine Neos||Ｅ・ＨＥＲＯ マリン・ネオス||WATER||Warrior||8||2800||2300|
|Elemental HERO Neos Knight||Ｅ・ＨＥＲＯ ネオス・ナイト||LIGHT||Warrior||7||2500||1000|
|Elemental HERO Storm Neos||Ｅ・ＨＥＲＯ ストーム・ネオス||WIND||Warrior||9||3000||2500|