This card is ideal to use against "Number 101: Silent Honor ARK", as a "Number 101" that activated its effect normally has no remaining Xyz Materials, meaning this card will be able to destroy it and prevent the targeted monster from being attached (since "Number 101" is no longer on the field).
While monsters normally do not have to remain face-up on the field for their activated effects to resolve, meaning that this card can only destroy them without preventing their effects from resolving, this card can be especially effective against those that do need to remain on the field, such as "Dark Paladin", "Naturia Beast", "Zombie Master" etc.
Keep in mind that this card can also use its effect while face-up on the field, meaning that cards like "Emergency Teleport" and "Call of the Haunted" can be helpful for preempting the opponent's actions.
In some situations, it is possible to protect a card from being destroyed by this card by properly building the Chain. For example, when Synchro Summoning "Baxia, Brightness of the Yang Zing" using "Denglong, First of the Yang Zing" as the Tuner, the effect of both monsters will activate. In that scenario, placing the shuffling effect of "Baxia" as Chain Link 1 and the Special Summon effect of "Denglong" as Chain Link 2 or higher will protect "Baxia" from being destroyed by this card.