This card works well with "Creature Swap" if the Spell is used after your Battle Phase and your opponent has another Monster. It ensures that you'll have a Monster to protect yourself with after this card is destroyed by its own effect.
Use the FIRE support card, "Backfire", in conjunction with this card; when this card destroys itself, your opponent takes additional damage.
This card combos well with "Michizure", which allows it to drag an opponent's monster with it when it destroys itself.
This card can be Special Summoned from the Deck by "Flamvell Firedog" and either deal a direct attack or destroy other monsters before destroying itself.
Or, rather than letting it destroy itself, use the 2 to Xyz Summon a Rank 4 Xyz Monster.
This card works well with "Mystik Wok", which will make you gain 2000 Life Points before destroying itself.
This card is great with "Compulsory Evacuation Device". Summon it, tribute 2 pyros, attack, use the "C.E.D" to return it to your hand, and with the right cards, you can remove from play the tributed Pyros to Special Summon more Pyros like "Spirit of Flames" and "Inferno" on your next turn ("Magical Mallet" helps you get the right cards), Normal Summoning "Gaia" again and repeating the process. Once you run out of Pyro Tributes, use "Spiritual Fire Art - Kurenai" to Tribute it and inflict 2000 points of Direct Damage. If you feel like an easy win, use "Curse of Anubis" BEFORE summoning your "Gaia", if your opponent's Deck isn't a Normal Monster Deck.
Use "Destruct Potion" on this card before it would be destroyed to gain 2000-4000 life points.
This card can be combined with "Begone, Knave!" to ensure that it comes back to your hand each time it inflicts damage, protecting it from its own effect.
If you like, you can use "Forbidden Chalice" instead of "Skill Drain" to negate this card Effect and preventing it of being destroyed by its own effect during the End Phase. Better used after this card already attacked