The easiest way to activate this card is to let your opponent Set 3 cards, then activate 2 of your own in a Chain, and then activate this card.
This card can be activated in response to the activation of your opponent's card, destroys a Field Spell Card on your field and the card activated by the opponent. Destroys 2 Set cards your opponent control and 1 Set "Z-ONE" on your field, to recover your Field Spell Card.
Cards on your field that can't be destroyed can be targeted to use this card without losing other resources.
This card can be activated to destroy a Synchro Monster(s) equipped to a "Meklord Emperor" monster controlled by your opponent and destroy 3 Set cards.
In an "Exodia OTK" Deck, this card can be activated in chain to 3 "Good Goblin Housekeeping" to destroy 2 "Good Goblin Housekeeping" and 3 Set cards controlled by your opponent, and finally 9 cards are drawn and return only 3.
This card works well with "Temple of the Kings." If you opponent tries to use cards like "Mystical Space Typhoon" or simply responding to one of your own Spell/Trap Cards, then this card can respond. If there no other face-up Spell/Trap Cards, then this card can simply target their "Mystical Space Typhoon" and "Temple of the King" to meet the face-up requirements. Since the first effect of "Temple of the Kings" might be used with this card, that card might not be needed and a lot of your opponent's Set Spell/Trap Cards will still be destroyed.
Due to the Master Rule 4 setting Pendulum Scales being in the left and rightmost of the Spell/Trap Zone, this card can be used to destroy two Pendulum Cards in the Pendulum Zones, and potentially the three remaining set cards the opponent likely has left.