The easiest way to activate this card is to let your opponent Set 3 cards, then activate 2 of your own in a Chain, and then activate this card.
This card is a relatve theat against Pendulum-based deck, as there would be 2 face-up card in Pendulum Zones and possibly up to 3 face-down cards.
Cards on your field that can't be destroyed can be targeted to use this card without losing other resources.
Alternatively, destroy cards that recover your resource.
This card can be activated to destroy a Synchro Monster(s) equipped to a "Meklord Emperor" monster controlled by your opponent and destroy 3 Set cards.
In an "Exodia OTK" Deck, this card can be activated in chain to 3 "Good Goblin Housekeeping" to destroy 2 "Good Goblin Housekeeping" and 3 Set cards controlled by your opponent, and finally 9 cards are drawn and return only 3.