- You can use this card in a "Venom" Deck as a last resort.
- This card also works well as a last resort in an "Alien" Deck, as "Aliens" typically do not have many extremely powerful monsters.
- You can use "DNA Surgery" to set the Type of your monsters on the field to Reptile, and then Special Summon this card.
- If your opponent doesn't have any cards on their field during your End Phase, then use "Samsara Lotus" or "Black Ptera" to save your cards from being destroyed.
- Use "Future Fusion" and select "Worm Zero" to send most of your "Worm" monsters to Graveyard and Special Summon this card to perform OTK.
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