If there is at least one "Cyber Dragon" in your Deck, it is probably wise to throw this card into your Extra Deck as general anti-Machine support, since doing so will not disturb the balance of cards in your Deck. As well, even non-Machine-Type Decks often use "Cyber Dragon", so this card can be used to remove it from the field as long as there is another face-up Machine-Type on either field.
"Chimeratech Fortress Dragon" can be Summoned even if there is no "Cyber Dragon" or any Machines on your field. If your opponent has the necessary Fusion Materials, they can be send to the Graveyard to Special Summon this card.
Use "DNA Surgery" to pull out "Chimeratech Fortress Dragon" easier while clearing your opponent's field for attacks. Reaching up to 10000 ATK.
Use "Light of Intervention" to prevent your opponent from setting monsters and keeping them face-up to use them as Fusion Materials.
Consider using "Level Eater" on "Cyber Dragon" to gain another 1000 ATK.
This card acts as a powerful counter-card against the popular "Cyber Dragon", as it can be used to remove the "Cyber Dragon" and other Machine-Type monsters your opponent controls, while Summoning a monster with at least 2000 ATK to your field.
It is important to note that "Chimeratech Fortress Dragon" will not be Summoned while "Macro Cosmos", "Dimensional Fissure", or a similar card is on the field since it requires monsters to be sent to the Graveyard.
Use "Creature Swap" to take control of your opponent's non-Machine-Type monster, while giving them control of your "Cyber Dragon" or other Machine-Type monster. Then use the monster that was just given away, as Fusion Material for this card.