"Infinite Cards" can increase the amount of damage inflicted by this card's effect, particularly since it also removes the hand-size limit of your opponent as well; more cards to discard means more damage is inflicted.
This card can also serve as back-up for your "Slifer the Sky Dragon". If "Slifer" were to be destroyed and you still have extra cards in your hand, you can Special Summon this card and possibly inflict massive damage.
With the new "Red-Eyes" support cards, this card's Nuking effect can be fatal. Activate this card's effect while you control "Meteor Black Comet Dragon" and "Black Metal Dragon". Your opponent's field will be empty and they will be handless, while your sent Monsters' effects will give you "Red-Eyes B. Dragon" for Tributing and "Red-Eyes Darkness Dragon" to attack directly with. In addition, you will dump several Dragons into the Graveyard to power REDD up, and your opponent will take 300 damage for each card that was wiped out. If your opponent even survives your turn, they will likely have to rely on Top-Decking.
Because the burn damage is not simultaneous, it can trigger several of your opponents card effects to miss timing such as Yubel -Terror Incarnate. Keep in mind that your effects will not trigger such as Light Pulsar Dragon.
This card's Nuke effect is a good way to counter the "Timelords", since it sends them to the Graveyard instead of destroying them outright.
Activate this card's effect, then chain "Ring of Destruction" and target "Chaos Emperor Dragon - Envoy of the End" for an extra 3000 damage. However, this will set you back 4000 LP with the combined effects, so it's best to use this strategy if it will reduce your opponent's Life Points to zero so you don't leave yourself open to a direct attack.
Use this card's effect while "Night Assailant" is in-hand to guarantee having a monster in the following turn. "Spear Cretin" is a good candidate.