In a Dragon Deck, this card can be used in conjunction with "Return of the Red-Eyes" or "Azure-Eyes Silver Dragon" to draw 1 card each turn in a small controlled loop. However, "Return of the Red-Eyes" can also summon on your opponent's turn.
This card works extremely well in a "Quickdraw Turbo" Deck. "Junk Synchron" Special Summons from the Graveyard "Quillbolt Hedgehog", "Doppelwarrior" or "Synchron Explorer". "Level Eater" Special Summons itself from the Graveyard by lowering the Level of a Synchro Monster or "Quickdraw Synchron". "Quillbolt" can also Special Summon itself from the Graveyard if you have a Tuner monster on the field. "Synchron Explorer" can Special Summon "Quickdraw" or "Junk" from the Graveyard. In all of these situations, you will be able to draw a card.
In a "Lightsworn" Deck, this card also useful; e.g. by using the effect "Lumina, Lightsworn Summoner" to Special Summon a "Lightsworn" monster while "Card of Safe Return" is active, its controller will be able to draw, increasing their chances of drawing "Judgment Dragon" before it is milled by the effect of a "Lightsworn" monster.
Using the Faultroll Loop in combination with this card creates an infinite draw cycle because "XX-Saber Ragigura" can be Special Summoned from the Graveyard when "XX-Saber Faultroll" is Special Summon from the hand, allowing its controller to draw a card.
This card can make the "Plaguespreader Hedgehog" loop endless if your control 1 "Imperial Iron Wall". Use the effect of "Plaguespreader Zombie" to Special Summon itself from the Graveyard, then draw again the same card returned to the top of your Deck. After that, use the effect of "Quillbolt Hedgehog" to Special Summon itself from the Graveyard too, then, you can both of these monster to Synchro Summon 1 Level 4 monster from your Extra Deck or use them to Xyz Summon Rank 2 monsters. If you use them to Synchro Summon monster, you can keep using them on Level 4 monster like "Armory Arm", "Phonon Pulse Dragon" and "Balmung, Fighter from the Underworld" and tune them to Synchron Summon horrors like "Shooting Quasar Dragon" or "T.G. Halberd Cannon".