This combo will only work if you have the right amount of "B.E.S." and "Big Core" cards. If you have either the "B.E.S" or the "Big Core" with "Boss Rush" on the field, use "Limiter Removal" to double the attack points of the monster. When the monster is destroyed, you can bring a stronger "B.E.S." or a "Big Core" to the field.
The effects of multiple "Boss Rush" stack, but remember that you only need to have one "B.E.S." or "Big Core" monster destroyed each turn. Therefore, if you have 2 copies of "Boss Rush" on the field, Special Summon "B.E.S. Big Core MK-2" and then any other "B.E.S." monster. The former will gain shields and remain on the field, while the latter will trigger "Boss Rush" after a single battle, since it will have no shields.
In a deck based around this card, be sure to include copies of cards like "The Tricky", "Cyber Dragon" and "Tragoedia" - monsters that can Special Summon themselves. They can provide Tribute fodder, help press an attack, or stall for time if you have "Boss Rush" on-field but no "B.E.S." monsters.
Alternately, use Trap Monsters to defend your Life Points. They can also serve as Tribute fodder for your monsters "B.E.S." and "Big Core" in the event that they are removed from the field without being destroyed.
"B.E.F. Zelos" can provide the monsters Special Summoned by this card with a counter in order to let them survive longer.