In episode 31, Camula uses this card during her duel against Vellian Crowler. She Normal Summons this card on the first turn of the duel. "Ancient Gear Soldier" (whose ATK was 1600 due to it being powered up by the effect of "Ancient Gear Castle") then attacks and destroys this card. Camula then activates this card's effect to Special Summon another copy with 500 more ATK. After Camula summons "Vampire Bat", the latter's effect increases this card's ATK by 200. The second copy then attacks and destroys "Ancient Gear Soldier". Later Crowler uses "Ancient Gear Beast" to attack and destroy this card. Due to the effect of "Ancient Gear Beast", the effect of this card is negated. After Crowler activates "Heavy Storm" to destroy Camula's set "Zombie Bed", the latter's effect activates, allowing Camula to Special Summon a third copy. The new copy then gains 200 ATK due to the effect of "Vampire Bat". On the final turn of the Duel, "Vampire Genesis" (whose ATK was 3200 due to the effect of "Vampire Bat") attacks and destroys "Ancient Gear Golem". This card and "Vampire Bat" then attack directly, defeating Crowler.
In episode 33, Camula uses this card during her duel against Jaden Yuki. She Normal Summons this card in Attack Position. "Elemental HERO Tempest" (who was summoned to Camula's side of the field via "Illusion Gate") then attacks directly. Camula then tries to use this card to attack directly, but Jaden activates "Cross Heart" to take control of "Tempest", saving himself. Jaden then uses "Tempest" to attack and destroy this card. Camula then activates this card's effect to Special Summon another copy with 500 more ATK. Camula then Tributes the second copy in order to Tribute Summon "Vampire Lord". Later Camula activates the effect of "Vampire Genesis" to discard "Ryu Kokki" and Special Summon this card from the Graveyard. Camula then activates "Giant Trunade" to return Jaden's set card to his hand. The effect of Jaden's "Insurance" then activates, allowing Jaden to gain 500 Life Points. "Vampire Genesis" then attacks and destroys "Tempest", Camula uses this card to attack directly, but (to her shock) Jaden did not lose the duel. Jaden then revealed that the set card returned to his hand was "Insurance", which gave him 500 Life Points before Camula attacked with "Vampire Genesis". After "Elemental HERO Shining Flare Wingman" attacks and destroys "Vampire Genesis", "Genesis Crisis" was destroyed. Since "Genesis Crisis" was destroyed, this card was destroyed too due to the final effect of "Genesis Crisis".