In episode 118, Thelonious Viper uses this card during his Duel against Jaden Yuki. He Tribute Summons this card by Tributing "Venom Boa" and "Venom Serpent". Since there are three Reptile monsters in Viper's Graveyard, this card gains 1500 ATK due to its second effect. This card then attacks and destroys "Elemental HERO Plasma Vice" (whose ATK was 800 due it being weakened by the effect of "Venom Swamp"). This card later gained 500 more ATK when Viper discarded "Venom Snake" for the cost of "Snake Deity's Command". On Viper's next turn, this card attacks and destroys "Elemental HERO Bubbleman" (whose ATK was 1100 due to it being equipped with "Bubble Rod" and weakened by the effect of "Venom Swamp"). Jaden then activates "A Hero Emerges" to make Viper choose one card in his hand. Viper selects one card and Jaden reveals it to be "Elemental HERO Neos", which allows Jaden to Special Summon the latter monster from his hand. This card later gained 500 more ATK when the "Venom Snake" in Viper's hand was destroyed by the effect of "Elemental HERO Marine Neos". "Marine Neos" then attacks and destroys this card. Viper then activates this card's third effect to banish one "Venom Snake" from his Graveyard and revive this card. This card's ATK then became 2000 due to its second effect. This card later gained 500 more ATK when Viper sent "Venom Serpent" from his hand to the Graveyard for the cost of "Venom Shot". This card then attacks and destroys "Marine Neos" (whose ATK was 1300 due to it being weakened by the effect of "Venom Swamp"). In the next episode, this card attacks directly, but Jaden banishes "Necro Gardna" from his Graveyard via its own effect to negate the attack. Later "Elemental HERO Wildedge" attacks and destroys this card. Instead of reviving this card through its own effect (which Jaden wanted to happen in order to create an infinite loop through the effect of "Wildedge"), Viper activates "Rise of the Snake Deity" to Special Summon "Vennominaga the Deity of Poisonous Snakes".
Its attack name is Venom Blow in the original and Fang Venom in the dub.