Kaiba uses this card during his Duel against Yami Yugi. He activates this card to banish all three Egyptian God cards from the field. Later Anubis urges Kaiba to finish Yami Yugi off, however Kaiba wanted a perfect victory, so he tried to use the Shining Nova effect of "Blue-Eyes Shining Dragon" to destroy this card, but this card was protected by Anubis as he would not allow this card to be destroyed. Anubis then took over the duel and tossed Kaiba aside. Anubis then uses this card's presence to Special Summon "Andro Sphinx" and "Sphinx Teleia" from his hand. Later Yugi Muto exploits a weak point in this card's power. Yami Yugi notices this and decides to use this chance to destroy this card. Yami Yugi then activates "Double Spell" to activate Kaiba's "Monster Reborn" from the Graveyard and revive "Blue-Eyes Shining Dragon" under his control. Yami Yugi then activates the Shining Nova effect of "Blue-Eyes Shining Dragon" to destroy this card. This time the attempt was successful. After this card was destroyed, "Andro Sphinx" and "Sphinx Teleia" were both destroyed as well. This however allows Anubis to Special Summon "Theinen the Great Sphinx".
"Pyramid of Light" removed from play all "Egyptian God Cards" on the field when activated. Although it had a different lore on the card, it still had the TCG/OCG real life effect, because when it was destroyed by "Blue-Eyes Shining Dragon", "Andro Sphinx" and "Sphinx Teleia" were destroyed as well.