- In episode 3, Mr. Kay plays this card against Yuma Tsukumo. He overlays "Crashbug X", "Crashbug Y" and "Crashbug Z" to Xyz Summon it. He uses its effect to detach the overlaid "Crashbug Y" and control of Yuma's "Gogogo Golem" until the End Phase. In the next episode, Mr. Kay takes control of "Gogogo Golem" a second time using this effect, and attacks directly via the effect of "Infected Mail", while dealing damage with "Cracking" when "Infected Mail" destroys "Gogogo Golem". He later detaches the final Overlay Unit to take control of Yuma's "Achacha Archer". It attacks directly with "Infected Mail", but Yuma negates the attack by detaching "Ganbara Knight" from"Number 39: Utopia" to the Graveyard. When Mr. Kay Special Summons "Super Crashbug", this card switches to Attack Position and its ATK and DEF switch. Mr. Kay uses it to attack "Utopia", but Yuma negates the attack by detaching an Overlay Unit Its stats return to normal when Yuma destroys "Super Crashbug" with "Asleep at the Switch". Yuma attacks and destroys it with "Number 17: Leviathan Dragon"
- In episode 65, Yuma plays this card against Vetrix. He overlays the Level 2 "Flelf" and "Bacon Saver" in his hand to Xyz Summon it via the effect of "Sphere Field. In the next episode, Yuma plays "Xyz Triangle Force" to destroy Vetrix's "Number 30: Acid Golem of Destruction" as he controls this and two more Xyz Monsters - "Utopia" and "Leviathan Dragon". He then Tributes this card with "Seven Store" to draw three cards.
- In episode 76, Yuma plays this card against Devon Knox. He overlays "Rai Rider", "Zubaba Knight" and "Mimimic" to Xyz Summon it. Its Overlay Units are taken by "CXyz Coach Lord Ultimatrainer" when its Summoned via "Rank-Up-Magic Barian's Force". This card is then attacked and destroyed by "Ultimatrainer", as that card negates this card's effect that prevents its destruction by battle.
- In episode 82, this card is amongst the "Numbers" shown with Astral in the Emperor's Key.
- In episode 112, this card is amongst the "Numbers" that appear in spirit with Yuma as he recalls his time with Astral.
- In episode 146, this card appears in the montage of "Numbers" in the Summoning sequence of "Number 99: Utopic Dragon".
- In A Basic Lecture of Dueling from Yuma and Astral, this card appears in a flashback to episode 76.
- This card's effect name in the Japanese version is "Bug Virus".