In episode 126, Yami Marik uses this card during his Duel against Joey Wheeler. He targets Joey's "Rocket Warrior" for this card's effect, immobilizing it. On Yami Marik's next Standby Phase, the effect of this card activates, inflicting 500 damage to Joey. After Joey Special Summons "Jinzo" through the effect of "Question", the effect of "Jinzo" destroys this card and frees "Rocket Warrior" from this card's effects.
In episode 76, Syd uses this card during his Ground Duel against Jack Atlas. When "Multiple Piece Golem" attacks "Assault Wheel", Syd activates this card to forbid "Multiple Piece Golem" from attacking or changing its battle position. On Syd's Standby Phase, this card's second effect activates, inflicting 500 damage to Jack. On the final turn of the Duel, Jack tunes "Multiple Piece Golem" (who is Level 6 in the anime) with "Sinister Sprocket" in order to Synchro Summon "Chaos King Archfiend". Since "Mulitple Piece Golem" had been removed from the field, this card is destroyed.
Notably, unlike its other appearances, in which the target was strapped into the wheel and stretched, "Nightmare Wheel" instead landed on "Multiple Piece Golem" and began crushing it under its weight.