In episode 72, Howard X Miller uses this card during his duel against Jaden Yuki. Right after Jaden started his turn, X activates this card. Jaden then uses this card's effect to Special Summon "Neo-Spacian Glow Moss" from his Deck. "Monster Register" then sends the top three cards of Jaden's Deck to the Graveyard due to "Glow Moss" being Level 3. This card remained on the field until the Duel was over.
X was exempt from the effect of this card due to his "Trap Sluzer" rendering him immune to this card's effects.
For the remaining turn where this card could have been used (Jaden's final turn), its effect did not activate. There is a possibility that, for the moment where it could have activated, Jaden had no Level 4 or lower monsters left in his Deck. Later in the turn, his Deck gains 4 legal targets ("Elemental HERO Electrum"'s Fusion Material) but none of them were Special Summoned.