In episode 119, Jaden Yuki uses this card during his Duel against Thelonious Viper. He summons this card via "Polymerization". Jaden then equips this card with "Necro Shot". He then activates the latter card's effect three times to banish three Reptiles in Viper's Graveyard (two "Venom Serpents" and one "Venom Snake"). This causes "Vennominaga the Deity of Poisonous Snakes" to lose 1500 ATK. Since the effect of "Necro Shot" was used three times, it is destroyed. The second effect of "Necro Shot" then activates, allowing Jaden to send "Neo-Spacian Dark Panther" from his Deck to the Graveyard. This card then attacks and destroys "Vennominaga". The second effect of this card then activates, switching this card to Defense Position at the end of the Damage Step. Viper then activates the second effect of "Vennominaga" to banish the final "Venom Snake" in his Graveyard and revive "Vennominaga. On Jaden's End Phase, "Venom Swamp" places a Venom Counter on this card and decreases this card's ATK by 500. After Viper activates "Snake Rain" to send four Reptiles from his Deck to the Graveyard and increase the ATK of "Vennominaga" by 2000. he uses "Vennominaga" to attack and destroy this card. Jaden then activates this card's final effect to destroy "Vennominaga", but it doesn't work due to "Vennominaga" being unaffected by card effects.
In episode 161, Jaden uses this card during his Tag Duel with Alexis Rhodes against Chancellor Sheppard and Ms. Dorothy. He summons this card via "Polymerization". This card then attacks "Marshmallon". Due to the latter's effect, it is not destroyed, however Sheppard and Ms. Dorothy still take Battle Damage. Jaden then activates "De-Fusion" to return this card to the Extra Deck and Special Summon "Sparkman" and "Necroshade" from his Graveyard.