Yami Yugi uses this card during his Duel against Anubis (originally he was facing Seto Kaiba, but Anubis interrupted the Duel close to the end and took over). He uses this card to discard "Exchange" and activate the "Monster Reborn" in Kaiba's Graveyard as his card, allowing Yami Yugi to revive Kaiba's "Blue-Eyes Shining Dragon" under his control.
In episode 96, this card is shown in Dr. Eisenstein's hand during his duel against Jaden. He draws this card and "Non-Fusion Area" via the effect of "Brain Dragon". Eisenstein then uses the effect of "Brain Dragon" to place this card and "Non-Fusion Area" on top of his Deck in the order he chooses. He chooses to place "Non-Fusion Area" on top of his Deck and place this card as the second card on top of his Deck.