In episode 123, Fonda Fontaine uses this card during her duel against Jaden Yuki while the former was a Duel Ghoul. She Normal Summons this card on the first turn of the duel. After Jaden Fusion Summons "Elemental HERO Flame Wingman" via "Polymerization", Fonda activates "Dark Cure", which would normally increase Jaden's Life Points by half of "Flame Wingman's" ATK, but this card's effect changes the increase to damage. Fonda then activates "Brutal Potion" and equips it to this card. Since Jaden just took effect damage, "Brutal Potion" increases this card's ATK by 1000. On Jaden's End Phase, the effect of "Brutal Potion" expires. Later Fonda discards two "Burning Algae" for the cost of "Magical Stone Excavation". This activates the effect of both "Burning Algae", which would increase Jaden's Life Points by 2000 (1000 for each "Burning Algae" sent to the Graveyard), but this card's effect changes the increase to damage. "Brutal Potion" then increases this card's ATK by 1000. After Fonda uses "Burning Algae" to attack "Flame Wingman" and Jaden activates "Hero Barrier" to negate the attack, this card attacks and destroys "Flame Wingman". Jaden then activates "Hero Signal" to Special Summon "Elemental HERO Wildheart". Since the latter could not be targeted or affected by Trap Cards, Fonda could not activate the effect of "Dark Cure". On Fonda's End Phase, the effect of "Brutal Potion" expires. Later "Wildheart" attacks and destroys this card.
In both versions of the anime, this card's effect is called Anti-Cure. Its attack is called Infectious Wrap in the dub and Dark Sick Call in the original.
In the Game: Yu-Gi-Oh! World Championship 2008, Nurse Reficlue appears as an NPC in the Duel World 4: Darkness. She gives the player the option to change their face.