"Negate" vs. "Destroy" and Continuous Cards
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Chaining "Mystical Space Typhoon" or "Dust Tornado" to a Normal Spell, Normal Trap Card, Quick-Play Spell Card or Ritual Spell Card has no effect on gameplay, as it does not negate the card's effect. If such a card is activated and is destroyed by a card, its effect still resolves and the card used to destroy it is essentially wasted.
However, if you chain to a Continuous, Field or Equip Spell Card, or a Continuous Trap Card with "Mystical Space Typhoon" or "Dust Tornado", the card is no longer active because it is destroyed, and the effect does not resolve and disappears.
A Continuous Spell Card or Continuous Trap Card must remain on the field for it's effect to resolve; If you activate "Macro Cosmos", and your opponent chains "Mystical Space Typhoon" to its activation, then "Macro Cosmos" is destroyed, and its effect does not resolve; you do not get to Special Summon a "Helios - The Primordial Sun".
Example
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- Step 1: Player A activates "Raigeki."
- Step 2: Player B chains "Imperial Order" to negate the effect of "Raigeki".
- Step 3: Player A chains "Mystical Space Typhoon" (or "Dust Tornado") to destroy "Imperial Order."
The chain resolves in reverse.
- Step 3 resolves first. "Mystical Space Typhoon" destroys "Imperial Order" .
- Step 2 would resolve next. "Imperial Order" has been destroyed though and its effect disappears.
- Step 1 resolves last. "Raigeki's" effect activates as normal.
For exactly the same reason, if you chain "Mystical Space Typhoon" to "The Eye of Truth", "Future Fusion", "Premature Burial", or "Call of the Haunted", the effects from those cards do not resolve.